HEALTH SPORT MEDICINE - creatine conference 2015

 


PROF Theo Wallimann - President

Theo Wallimann studied at the Biology Department, ETH Zurich, where his dissertation in the laboratory of Prof. Hans Eppenberger on “ The localisation and function of MM-CK at the sarcomeric M-band“, completed 40 years ago in 1975, was awarded the ETH medal.  From 1975-1981 he was research associate with Prof. A.G.Szent-Györgyi at the Biology Dept., Brandeis University in Boston, USA, on "myosin-linked calcium regulation of muscle contraction". In 1981, he took up teaching and research at the Institute of Cell Biology,

 

ETH Zurich, in the areas of muscle biochemistry and bioenergetics. In 1984, he qualified as lecturer and in 1994, was awarded the title of Professor. He is an Emeritus since June 2008. The main emphasis of his research was on the ultrastructural localization, molecular structure and physiological function of creatine kinase (CK), creatine transporter (CRT) and AMP-activated protein kinase (AMPK) in tissues with high energy requirements, as well as the mechanisms of cytoprotection by creatine.


PROF Roger Harris - Co-President

BSc and PhD in biochemistry from the University of Wales, Aberystwyth. In 1968 I joined Drs Eric Hultman and Jonas Bergstrom at St Eriks Hospital, Stockholm, which in many ways was the cradle of exercise biochemistry as we know it today.  The next 8 years were, for me, some of the most exciting in exercise research, a time when the professor’s word was law.
The focus was initially on carbohydrate loading but already an interest in creatine and creatine-phosphoryltransferase in adenine nucleotide metabolism in

 

contracting muscle was developing. This set the seeds for studies in the 1990’s resulting in the description of creatine loading in muscle, and then later in the mid 2000’s to carnosine elevation by beta-alanine supplementation.  Both projects were borne from an interest in exercise biochemistry and it was incidental that these lead to inter-ventions for increasing exercise performance in athletes.  My last post was as Professor of Sport Science at the University of Chichester, from which I retired five years ago.

 


DR Maurizio Balestrino

Maurizio Balestrino was born in Genoa (Italy), the birthplace of Christopher Columbus and of the blue jeans. He received there the Degree in Medicine and the Diploma of Specialist in Neurology. In 1983-1986 he was Research Associate in the Department of Physiology at Duke University, where he learnt the technique of in vitro brain slices and started an interest in creatine and neuroprotection. Back in Italy he has combined clinical practice of neurology and preclinical experimental research.

 

He has carried out research on creatine as a neuroprotectant against anoxic and ischemic damage, and on the design, synthesis and effects of several creatine-derived compounds. He is currently Senior Researcher in the University of Genoa, where he has clinical duties in the Stroke Unit and also directs the Laboratory of Experimental Neurophysiology. He was, among else, the recipient of research grants on creatine and creatine-derived compounds from INTAS and from Telethon Italy.

 


ASSoc Prof Andreas Bender

Dr. Bender is associate professor for neurology at the University of Munich and is head of department of a hospital for neurological rehabilitation in southern Germany (Therapiezentrum Burgau). He is a specialist neurologist for neurorehabilitation and neurocritical care. His main areas of research expertise are mitochondrial dysfunction and mitochondrial DNA deletions in aging and neurodegeneration, neurorehabilitation, and prognosis after acute brain injury.
He has planned, conducted, and analysed

 

investigator-driven, prospective randomised clinical trials, e.g. on the neuroprotective potential of creatine in Parkinson´s disease. He is currently coordinating investigator of a neurorehabilitation research network, funded by the ZNS Hannelore Kohl Foundation. Current and recent funding comprise a DFG molecular biology project, a BMBF junior scientist group (IFB - German Center for Vertigo and Balance Disorders), a BMG trial of rehabilitation effectiveness, and an Else-Kröner-Fresenius Memorial Stipend.

Dr Olivier Braissant

Olivier Braissant, biologist, obtained his PhD thesis at the University of Lausanne, Switzerland, in 1994. After a post-doc
on nuclear receptors and their expression in CNS, he moved in 1997 to the University Hospital of Lausanne (CHUV) in the Clinical Chemistry Laboratory (now become Service of Biomedicine) of the Department of Laboratories. There, he started working on inborn errors of metabolism affecting brain development. He is “Privat Docent” and “Maître d’Enseignement et de Recherche”
of the University of Lausanne,

 

and Head of Research Section. His research interests focus on brain development andmetabolism, and how various inborn errors of metabolism can affect them. Olivier Braissant has become one renowned expert in the field of creatine metabolism and transport in the brain, and the way cerebral creatine deficiency syndromes affect them. He is author of about 70 papers published in international journals and conference proceedings, as well as invited book chapters.

 


Prof john t. brosnan

John (Sean) Brosnan is University Research Professor in the Department of Biochemistry, Memorial University of Newfoundland in Canada and Adjunct Professor of Pediatrics (Nutrition) at Baylor College of Medicine in Houston, Texas, USA. He received his DPhil from Oxford University, UK, working with Sir Hans Krebs, and spent three years as a post-doctoral fellow in the lab of Irving Fritz at the University of Toronto, Canada Sean joined Memorial University in 1972.

 

 

He has had a long-term interest in amino acid metabolism. His current research interests include creatine synthesis and function, one-carbon metabolism and the hepatic zonation of metabolism. He has served as President of the Canadian Society for Biochemistry and Molecular Biology and is a Fellow of the Royal Society of Canada. He has served on  the editorial boards of the Biochemical Journal, the Journal of Biological Chemistry, and Current Opinion in Clinical Opinion and Metabolic Care.


Prof Louise Burke

Louise is a sports dietitian with over 30 years experience in the education and counselling of elite athletes.  She has been Head of Sports Nutrition at the Australian Institute of Sport since 1990.  She was the team dietitian for the Australian Olympic Teams for the 1996, 2000, 2004, 2008 and 2012 Olympic Games.  Louise’s publications include over 200 research papers in peer-reviewed journals and book chapters, and the authorship or editorship of several textbooks on sports nutrition. 

 

She is an editor of the International Journal of Sport Nutrition and Exercise Metabolism.Louise was a founding member of the Executive of Sports Dietitians Australia and is a Director of the IOC Diploma in Sports Nutrition. She is a member of the Working Group on Nutrition for the International Olympic Committee and was awarded a Medal of the Order of Australia in 2009 for her contribution to sports nutrition.

 


Assoc prof darren G. candow

Darren Candow, PhD, is an Associate Professor in the Faculty of Kinesiology & Health Studies, University of Regina, Canada. Dr. Candow serves as Associate Editor for the Journal of Aging and Physical Activity and sits on the editorial review board for the Journal of Biogerontology, Journal of the International Society of Sports Nutrition, and The Scientific World Journal-Nutrition Division.

 

Dr. Candow's research program involves the development of effective resistance training and nutritional intervention strategies for improving properties of aging muscle and bone health. Dr. Candow's research is funded by the Canadian Institutes of Health Research (CIHR), Canada Canada Foundation for Innovation (CFI), the Saskatchewan Health Research Foundation (SHRF), and the Nutricia Research Foundation.

 


Prof rafael deminice

Prof. Rafael Deminice obtained his PhD from Faculty of Medicine, University of Sao Paulo in 2010. He joined Memorial University of Newfoundland (Canada) as visiting researcher (2010) and Nutrition and Metabolism Laboratory at University of Sao Paulo as post-doctoral fellow in 2011. Currently he is head of Laboratory of Biochemistry Applied to Nutrition and Exercise at the Faculty of Sport and Physical

 

 

Education at the State University of Londrina, Brazil.
His research interests include creatine supplementation and physical exercise interactions on one-carbon metabolism under different pathological situations. In the last years, his team has described therapeutic effects of creatine supplementation on experimental fatty liver disease and cancer.

 


dr hayley dickinson

Hayley Dickinson is a reproductive physiologist and obtained her PhD from Monash University in 2006. She is currently an NHMRC Biomedical Career Development Research Fellow at the Ritchie Centre; the research arm of the Monash University Departments of Obstetrics and Gynaecology, Monash Newborn and Paediatrics at Monash Medical Centre. Her research is aimed at

 

saving babies lives and reducing the long-term burdens (health, emotional and economic) of major perinatal conditions such as birth asphyxia. She has developed a model of birth asphyxia in a precocial rodent and shown long-term, multi-organ protection of maternal dietary creatine supplementation for the offspring. She now leads a series of clinical studies aimed at unravelling the role of creatine in pregnancy.

 


dr stacey ellery

Stacey completed her PhD at The Ritchie Centre, Monash University Australia, in September of 2014. The focus of her PhD studies was an investigation of the adverse outcomes of birth asphyxia on renal function, together with an evaluation of prenatal [maternal] administration of creatine to protect the fetal/neonatal kidney. Stacey has now taken on a postdoctoral position at The Ritchie Centre, where she intends to extend

 

 

the work completed during her PhD, but with a focus on maternal nutrition, factors leading to fetal growth deficiencies and energy homeostasis during pregnancy. Stacey is specifically interested in investigating whether adjustments to maternal energy homeostasis during pregnancy can improve outcomes where fetal growth retardation, preterm birth, and birth asphyxia are at high risk.


PROF  W. Ross Ellington

W. Ross Ellington is the Michael J. Greenberg Professor of Biological Science and Associate Vice President for Research at Florida State University (Tallahassee, Florida). He was trained as a comparative biochemist / physiologist at the University of Rhode Island and subsequently did postdoctoral work in enzymology. The bulk of Dr. Ellington’s career has been spent at Florida State University. Early work involved studies of energetics and intracellular acid-base balance in marine invertebrate muscle systems utilizing a broad

 

range of techniques including multi-nuclear NMR spectroscopy. These efforts led to a pre-occupation with phosphagen systems which continues to this day. In recent years, Dr. Ellington’s research focus has been at the interface of biophysics, cell biology and evolution. This has involved productive collaborations with structural biology as well as molecular evolution groups. Experimental efforts have spanned the phylogenetic spectrum from basal chordates to unicellular, eukaryotic protists.


Prof bruno gualano

Prof Bruno Gualano has served as a Professor at University of Sao Paulo since 2010, where he is the head of the Laboratory of Nutrition and Metabolism Applied to Exercise (School of Physical Education and Sport) and the head of the Laboratory of Evaluation and Conditioning in Rheumatology (School of Medicine). He has also been a Visitor Professor at Nottingham Trent University (England) and Wintec University (New Zealand).

 

His main research interests cover the therapeutic role of exercise and sports nutrition. Currently, Prof Gualano has been involved as a primary researcher in a number of RCTs aimed to advance the knowledge on the efficacy and safety of creatine supplementation in a variety of populations, including athletes, healthy and diseased individuals.


Prof Dirk Isbrandt

Dirk Isbrandt is a University Professor of Experimental Neurophysiology at the DZNE (German Center for Neurodegenerative Diseases) in Bonn and the University Hospital of Cologne, Germany. He discovered the first mutation in a creatine synthesis defect in a patient with GAMT deficiency.

 

 

His research is aimed at investigating the physiological role of creatine and the pathophysiology of creatine synthesis disorders using genetic mouse models. In the last years, his team has focused on generating and analyzing the phenotypes of AGAT- or GAMT-deficient knockout mice.


pROF ARend heerschap

Arend Heerschap studied biochemistry at the Free University Amsterdam and obtained his PhD at the University of Nijmegen on “The solution structure of tRNA as viewed by NMR” in 1984. After a position in MR (pre-)development at Philips Research Laboratories (Eindhoven) and Philips Medical Systems (Best) from 1984 – 1989 he became assistant professor at the Faculty of Medical Sciences of the Nijmegen University. Since 1998 he is professor and head ‘Experimental biomedical MR research’ group at the University Medical Center Nijmegen (UMCN). His overall research aim is to exploit the exquisite capabilities of MR in

 

“molecular” and “biological” imaging to address biomedical questions and problems. The utilization of MR at the fundamental and applied level helps to understand disease processes and to improve diagnostics and treatment evaluation in clinical examinations. The translational aspect is important, involving complementary animal and human studies.
He has developed a research program focusing on biomedical questions in oncology and intermediate (energy) metabolism. These have been mainly applied to tissues like prostate, brain, liver, and skeletal muscle.


Prof Richard B. Kreider

Dr. Kreider serves as Professor, Department Head, and Thomas A. and Joan Read Endowed Chair for Disadvantaged Youth in the Department of Health & Kinesiology at Texas A&M University.  Dr. Kreider also directs the Exercise & Sport Nutrition Lab.  Dr. Kreider has conducted numerous studies on nutrition and exercise and has published three books, more than 500 research articles and abstracts in scientific journals, and over 150 articles for health and fitness magazines.  This includes conducting research on the safety and efficacy of creatine supplementation since 1994. 

 

Dr. Kreider is a Fellow of the American College of Sport Medicine (ACSM); an active member of the National Strength and Conditioning Association (NSCA); a founding board member and Fellow of the International Society of Sports Nutrition; and, founding Editor-In-Chief of the Journal of the International Society of Sports Nutrition.  Dr. Kreider has received over 12 million dollars in external funding to support research related to the role of exercise and nutrition on health, disease, rehabilitation, and performance.


assoc prof craig A. lygate

I am a University Research Lecturer and Head of Murine Cardiac Phenotyping in the Division of Cardiovascular Medicine at the University of Oxford. I originally studied Pharmacy at the University of Strathclyde in Glasgow, completing my training at the Royal Infirmary of Edinburgh. Quickly realising that research was the life for me; I did a Masters in Biological Sciences in Manchester and a PhD in Cardiovascular Physiology at the University of Glasgow. I started in Oxford as a fresh-faced post-doc in 2000 in the

 

 laboratory of Prof Stefan Neubauer and have stayed ever since. We continue to work closely together and I take the lead on the basic science aspects of our research. For many years we have worked with genetically-modified models of altered creatine metabolism, most recently with a particular interest in the creatine transporter. Ultimately our research aims to establish the therapeutic potential of augmenting cardiac energetics in the diseased heart.

 


Prof ron j. maughan

Ron Maughan obtained his BSc (Physiology) and PhD from the University of Aberdeen, and held a lecturing position in Liverpool before returning to Aberdeen where he was based in the Medical School for almost 25 years. He spent much of this time working on a range of projects relating to the effects of diet and exercise on muscle metabolism.
He was then Professor of Sport and Exercise

 

Nutrition at Loughborough University for 10 years and now has an emeritus position there. He chaired the Human and Exercise Physiology group of the Physiological Society for 10 years, and now chairs the Sports Nutrition Working Group of the Medical Commission of the International Olympic Committee. He is also chair of the Science Advisory Board of the European Hydration Institute.

 


Prof Sergej M. Ostojic

Sergej M. Ostojic received his medical degree from the Faculty of Medicine, University of Belgrade, Serbia on September 1996. He then pursued his postgraduate training in exercise science & medicine and obtained PhD at the University of Belgrade in 2003. In 2002, he joined the faculty of the Institute of Sports Medicine at the Sports Academy Belgrade. Currently he is Director of Human Performance Laboratory at the Center of Health, Exercise and Sport Sciences, Belgrade and Professor at the Faculty of Sport and Physical Education at the University of Novi Sad.

 

His research is focused on physiological responses to maximal and submaximal exercise, and evaluation of the ergogenic properties of dietary agents. His current research is focused on safety and efficacy of oral administration of guanidinoacetic acid, creatine precursor, in health and disease. He is a member of American College of Sports Medicine, European Physical Conditioning Association and International Federation of Sports Medicine. He has a number of publications in different journals in medicine, physiology & sport science.

 


Prof Yannis p. Pitsiladis

Professor Pitsiladis has an established history of research into the importance of lifestyle and genetics for human health and performance. Following 15 years at the University of Glasgow (Institute of Cardiovascular and Medical Sciences) where he created the largest known athlete DNA biobank, he was appointed Professor of Sport and Exercise Science at the University of Brighton. Here he is in the process of establishing state-of-the-art laboratories in human systems biology with special applications to sport and exercise science, sports medicine and sports nutrition. His current research priority in the area of regenerative medicine is the application of “OMICS” (i.e. genomics, transcriptomics, metabolomics and proteomics) technologies to the study of injury predisposition and response to training and rehabilitation in order to uncover the underlying biological mechanisms.

 

His most recent research is funded by the World Anti-Doping Agency (WADA), he has sat on two WADA committees and an expert group of the International Olympic Committee (IOC). He is a member of the scientific commission of the International Sports Medicine Federation (FIMS), a Fellow of the American College of Sports Medicine (ACSM) and an expert committee pool member of the Biotechnology and Biological Sciences Research Council (BBSRC). He is an adjunct Professor of Medical Physiology at the University of Technology (Kingston, Jamaica), Moi University (Eldoret, Kenya) and Addis Ababa University (Addis Ababa, Ethiopia). He has published over 100 peer-reviewed papers, written and edited a number of books and has featured in numerous research documentaries (e.g. BBC, NHK Japan, CNBC) and popular books (e.g. Bounce, The Sports Gene).


Prof eric s. Rawson

Eric S. Rawson is a Professor in the Department of Exercise Science at Bloomsburg University of Pennsylvania.  Dr. Rawson received his Ph.D. from the University of Massachusetts, Amherst where he studied under the direction of Dr. Priscilla Clarkson.  Over the past decade and a half, Dr. Rawson’s research has focused on the interactions between nutrition and skeletal muscle.  In particular, Dr. Rawson has studied the effects of the dietary supplement creatine on muscle and brain function.  Dr. Rawson is currently an Associate Editor for Applied Physiology, Nutrition, and Metabolism, Amino Acids, and the Journal of Strength and Conditioning Research

 

Dr. Rawson has delivered more than 100 professional presentations, is co-author of the 10th Edition of the text Nutrition for Health Fitness and Sport, and has authored/co-authored numerous articles and book chapters.  His research has been funded by the National Institutes of Health National Center for Complementary and Alternative Medicine, Bloomsburg University, and various foundations.  Dr. Rawson is a Fellow of the American College of Sports Medicine (FACSM).


Prof manju ray

Manju Ray obtained her PhD from Calcutta University, based on her work “Galactose metabolism and enzymatic regulation” in 1975. After that she was associated with Jadavpur University as a research scientist and took interest on cancer biochemistry and methylglyoxal research. The pioneering work of Dr. Manju Ray has firmly established methylglyoxal, the “enigmatic” ketoaldehyde for decades, in the biochemical map of intermediary metabolism.
In 1992 she joined Indian Association for the Cultivation of Science as Associate Professor and gradually upgraded to professor, senior professor and also served the institute as an academic dean and as director (acting). Currently she is an emeritus scientist at Bose Institute, India.

 

 

Dr. Manju Ray conclusively showed that methylglyoxal inhibits the respiration and glycolysis by inhibiting the electron flow through complex I of mitochondrial respiratory chain and exclusively inactivates glyceraldehyde-3-phosphate dehydrogenase of malignant cells resulting ATP depletion in malignant cells and rendering them non viable. Dr. Ray has also convincingly demonstrated that creatine/creatine kinase system would be a biomarker for progression of malignancy and can augment the anticancer effect of methylglyoxal. All these investigations developed the anticancer drug formulation with methylglyoxal using creatine as an adjuvant which is presently in Phase II/ Phase III clinical trial. She has total 75 publications in international journals and received various awards and honors.


Prof Perry renshaw

Dr. Renshaw is a graduate of the University of Pennsylvania School of Medicine.  He also holds a Ph.D. in Biophysics from the University of Pennsylvania and an M.B.A. from Bentley College.  Dr. Renshaw was formerly Director of the McLean Hospital Brain Imaging Center and a Professor of Psychiatry at Harvard Medical School.  In 2008, he relocated to the University of Utah, where he is a USTAR Professor of Psychiatry at the University of Utah. 

 

His training as a biophysicist and psychiatrist has led to a primary research interest in the use of multinuclear magnetic resonance spectroscopy to identify changes in brain chemistry associated with mood and substance abuse disorders. Dr. Renshaw’s research has been continuously supported by the NIH since 1994.

 


Dr lucia santacruz

Dr. Santacruz received her PhD in Physiology from the School of Medicine at the University of California, Los Angeles (UCLA), where she worked on Shaker potassium channels. Her postdoctoral training was at the Cardiovascular Research Institute in UCLA on the sodium-calcium exchanger, and at Baylor College of Medicine on the skeletal muscle ryanodine receptor. She then joined the faculty at Duke University Medical Center

 

where she began work on the Creatine Transporter structure and its regulation in health and disease. Dr. Santacruz currently holds an appointment at the Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, where she is continuing these studies, as well working on creatine supplementation as cardioprotection during doxorubicin chemotherapy.

 


Prof Gajja S. Salomons

Gajja Salomons was born in Amsterdam, The Netherlands. She obtained her PhD at the Netherlands Cancer Institute/University of Amsterdam. She is appointed as Professor at the Department of Clinical Chemistry of the VU University Medical Center in Amsterdam. She is the head of the Metabolic Laboratory, which employs enthusiastic technicians, analytical and organic chemists, cell biologists, scientists, and PhD students. Her laboratory provides diagnostics on inborn errors of metabolism on three levels: metabolites, enzyme and DNA. Her research is imbedded in the Neuroscience Campus Amsterdam. Her overall research aim is

 

on unraveling the cause of neurometabolic disorders, development of diagnostic approaches and translational research. One of her main interests is the cerebral creatine deficiency syndromes. The team of Gajja Salomons is (co)author on many papers related to this topic, including the paper reporting the underlying genetic defect of X-linked creatine transporter deficiency (Salomons et al 2001, Am J Hum Genetics). Her laboratory functions as a worldwide referral center, which created the unique possibility for a strong research program on creatine metabolism and transport for which Prof Salomons received prestigious awards and grants.

 


Prof UWE Schlattner

Uwe Schlattner is Professor at the University Grenoble-Alpes (formerly University Joseph Fourier), France, director of the “Laboratory of Fundamental and Applied Bioenergetics” (LBFA, Inserm U1055), as well as director of the Federative Research Structure “Environmental and Systems Biology”. After studies in Stuttgart and Freiburg i. Br. (Germany), he received in 1995 a Ph.D. in biology at the University of Geneva (Switzerland) and worked from 1996 to 2005 as postdoctoral fellow and associate professor (Privatdozent) with Prof. Theo Wallimann at the Department of Cell Biology, ETH Zürich (Switzerland).

 

Since 2006, he heads a group at LBFA-Inserm U1055 on “Molecular and Systems Bioenergetics”. Dr. Schlattner’s research interests are in cellular energetics and energy homeostasis, from molecular mechanisms to human health and disease, in particular the role of key kinase complexes. His earlier studies concentrated on structure and molecular physiology of creatine kinases, including the first atomic structures of the brain isoforms. More recent research involves the multi-functional nucleoside diphosphate kinase Nm23-H4 and the systems biology of energy and nutrient signalling via AMP-activated protein kinase.

 


Assoc prof Andreas schulze

Dr. Schulze is an expert in pediatric metabolic medicine with longstanding experience in diagnosis and management of patients with inherited metabolic diseases. He graduated from Medical School at the University of Leipzig, Germany, (Medical Diploma thesis: ‘Diagnostic Significance of Urinary Glucocorticoids’), received post-doctoral training in Physiological Biochemistry at the Institute of Biochemistry in Leipzig (PhD thesis: ‘Differential Gene Expression in the Postnatal Rat Liver’), and in Pediatrics at the University Children Children’s Hospital of the

 

Ruprecht-Karls-University of Heidelberg (Professorial thesis: ’Basics and Application of Tandem Mass Spectrometry in Inborn Errors of Metabolism’). He is actually an Associate Professor in Pediatrics at the University of Toronto. In the Research Institute of the Hospital for Sick Children in Toronto, Dr. Schulze has established a research laboratory with focus on Creatine metabolism that aims for elucidating the pathophysiology of the diseases, timely diagnosis, and especially the development of novel treatments.

 


Prof Piero sestili

Piero Sestili was born in Urbino, in the north-center of Italy, close to the Adriatic sea. Urbino is the birthplace of the reinassance painter Raffaello Sanzio which, honestly, is much more well known worldwide. In 1984 Piero Sestili earned a doctoral degree in Pharmacy.  Postdoctoral Fellow with a grant by the “Associazione Italiana per la Ricerca sul Cancro” from 1988 to 1990. Visiting scientist at the University of Texas “MD Anderson Cancer Center” in 1992, with a grant from NIH (Joint Program "USA-Italy Agreement on Cancer Research"). In 1994 he was appointed Assistant Professor at the Institute of Pharmacology of the University

 

of Urbino where, since 2001 he is Associate Professor of Pharmacology at the Department of Biomolecular Sciences. His main field of research interest is oxidative stress and oxidative DNA damage. He invented and developed the “Fast Halo Assay”, a genoxicity test operating at the single cell level. Since 2004 he’s working on the antioxidant and pleiotropic activity of creatine in different cultured cell systems, including differentiating myoblasts and primary neurons.  He has published over 100 peer-reviewed papers.

 


Prof Mark tarnopolsky

I am a professor of pediatrics and medicine and the division head of Neuromuscular and Neurometabolic Diseases.  I spend half of my time seeing patients with the above disorders and half of my time doing research that has relevance to the aforementioned disorders. My research interests include;

 

 

treatments for muscle and neurometabolic disease with a primary focus on mitochondrial cytopathies, diagnosis of neurogenetic disorders, understanding the biology of aging and the development of countermeasures for muscle dysfunction with aging.

 


Prof Robert G. Weiss

Robert G. Weiss, MD is the Clarence Doodeman Professor of Cardiology at the Johns Hopkins University in Baltimore, Maryland, USA. He is a cardiologist who had a long interest in myocardial metabolism and the use of noninvasive cardiac imaging

 

and spectroscopy techniques to study energy metabolism in the human heart.  Dr. Weiss has investigated the role of altered bioenergetics in heart failure, ischemia and in sudden cardiac death in both animal models of human disease and in patients.
 

 


Assoc prof yong-bin yan

Yong-Bin Yan, PhD, is an Associate Professor in the School of Life Sciences, Tsinghua University, Beijing, China. He received his Bachelor degree of Mechanics in 1997 and PhD of Biophysics in 2001 from Tsinghua University, and thereafter took up teaching and research at the same place. His main research interest is the cullular micro-

 

 

domains involved in protein, RNA and energy turnover. The current research topics include: physiological and pathological roles of creatine kinase with a focus on the identification of novel creatine kinase binding partners, molecular mechanisms of protein misfolding in ocular dysfunctions and mRNA turnover regulated by deadenylases.

 

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